Aranda 1..15
نویسندگان
چکیده
D o The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic model for epigenetic maintenance of gene transcription programs. Despite intensive research efforts to unveil the molecular mechanisms of action of PcG proteins, several fundamental questions remain unresolved: How many different PcG complexes exist in mammalian cells? How are PcG complexes targeted to specific loci? How does PcG regulate transcription? In this review, we discuss the diversity of PcG complexes in mammalian cells, examine newly identified modes of recruitment to chromatin, and highlight the latest insights into the molecular mechanisms underlying the function of PcGs in transcription regulation and three-dimensional chromatin conformation. w n
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Oscar Cordón Departamento de Ciencias de la Computación e Inteligencia Artificial, Universidad de Granada, Daniel Saucedo Aranda s/n, 18071 Granada, Spain, [email protected] European Centre for Soft Computing. Edificio Científico-Tecnológico, C/ Gonzalo Gutiérrez Quirós, s/n, 33600 Mieres (Asturias), Spain, [email protected] Sergio Damas Departamento de Lenguajes y Sistemas Info...
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